INHIBITION BY NON-STEROID ANTI-INFLAMMATORY AGENTS OF RABBIT AORTA CONTRACTING ACTIVITY GENERATED IN BLOOD BY SLOW REACTING SUBSTANCE C
作者： S.H. FERREIRA , B.B. VARGAFTIG
DOI: 10.1111/J.1476-5381.1974.TB08587.X
关键词: Methysergide 、 Aorta 、 Platelet 、 Autacoid 、 Arachidonic acid 、 Prostaglandin 、 Internal medicine 、 Anti-inflammatory 、 Endocrinology 、 Chemistry 、 Lipoxygenase
摘要: Abstract 1 A crude and a partially purified preparation of slow reacting substance C (SRS-C) as well arachidonic acid decreased resistance to perfusion the dog hind paw. This effect was suppressed by treatment with non-steroid anti-inflammatory drugs. 2 Injections SRS-C or induced marked reproducible contractions strips rabbit aorta rat stomach which were bathed in blood from an anaesthetized dog. The on is attributed formation contracting (RCS). when treated drug. 3 Incubation platelet-rich plasma resulted similar materials. drugs. 4 SRS-C, linoleic, linolenic, acids are suitable substrates for soybean lipoxidase generation RCS. 5 It suggested that RCS prostaglandin formed within platelets, injected into animals added vitro. Non-steroid drugs suppress these effects, possibly inhibiting synthetase.
sci-hub.se 参考文章(22)
Mats Hamberg, Bengt Samuelsson, On the Specificity of the Oxygenation of Unsaturated Fatty Acids Catalyzed by Soybean Lipoxidase Journal of Biological Chemistry. ,vol. 242, pp. 5329- 5335 ,(1967) , 10.1016/S0021-9258(18)99432-9
N. GILMORE, J. R. VANE, J. H. WYLLIE, Prostaglandins released by the Spleen Nature. ,vol. 218, pp. 1135- 1140 ,(1968) , 10.1038/2181135A0
PRISCILLA J. PIPER, J. R. VANE, Release of Additional Factors in Anaphylaxis and its Antagonism by Anti-inflammatory Drugs Nature. ,vol. 223, pp. 29- 35 ,(1969) , 10.1038/223029A0
R. GRYGLEWSKI, J. R. VANE, The generation from arachidonic acid of rabbit aorta contracting substance (RCS) by a microsomal enzyme preparation which also generates prostaglandins. British Journal of Pharmacology. ,vol. 46, pp. 449- 457 ,(1972) , 10.1111/J.1476-5381.1972.TB08142.X
B. B. VARGAFTIG, P. ZIRINIS, Platelet aggregation induced by arachidonic acid is accompanied by release of potential inflammatory mediators distinct from PGE2 and PGF2. Nature. ,vol. 244, pp. 114- 116 ,(1973) , 10.1038/NEWBIO244114A0
J. R. VANE, Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs Nature. ,vol. 231, pp. 232- 235 ,(1971) , 10.1038/NEWBIO231232A0
W. Vogt, Pharmacologically active substances formed in egg yolk by cobra venom The Journal of Physiology. ,vol. 136, pp. 131- 147 ,(1957) , 10.1113/JPHYSIOL.1957.SP005748
B. B. Vargaftig, Nguyen Dao Hai, Paradoxical inhibition of the effects of bradykinin by some sulfhydryl reagents. Cellular and Molecular Life Sciences. ,vol. 28, pp. 59- 62 ,(1972) , 10.1007/BF01928265
B.B. Vargaftig, N. Dao, Release of Vasoactive Substances from Guinea-Pig Lungs by Slow-Reacting Substance C and Arachidonic Acid Pharmacology. ,vol. 6, pp. 99- 108 ,(1971) , 10.1159/000136231
B. B. VARGAFTIG, E. P. DE MIRANDA, B. LACOUME, Inhibition by non-steroidal anti-inflammatory agents of in vivo effects of "slow reacting substance C". Nature. ,vol. 222, pp. 883- 885 ,(1969) , 10.1038/222883A0