The Effects of Pharmacological Preconditioning with GYKI-52466 and Domoic Acid on LTP and LTD Induction in the Rat Hippocampus

摘要: ii Acknowledgements iv Table of Figures viii Tables ix List Abbreviations x Introduction 1 The Need for ‘Brain Medicine’ 1.1 Preconditioning 2 1.2 1.2.1 Pharmacological 4 GYKI-52466 1.2.1.1 Domoic Acid 5 1.2.1.2 1.2.2 Metabotropic Involvement in 6 G-protein Linked AMPA and KA-Rs 7 1.2.2.1 1.2.3 Alternative uses preconditioning 8 Synaptic Plasticity 1.3 1.3.1 Hippocampus 9 Hippocampal Brain Slices 11 1.3.1.1 1.3.2 Long Term Potentiation 12 Early late LTP 13 1.3.2.1 1.3.3 Depression 14 1.3.4 Metaplasticity 15 Recent Findings the Kerr Lab: 1.4 1.4.1 GYKI as a nootropic agent 1.4.2 16 1.4.3 Chronic 17 Rationale Aims 1.5 Hypothesis 18 1.6 Materials Methodology 19 Animals 2.1 Reagents 2.2 Equipment 2.3