Long-Term Potentiation—A Candidate Cellular Mechanism for Information Storage in the Central Nervous System

摘要: Long-term potentiation (LTP) can be defined as a long-lasting change in output response to transient input. The persistence of this effect is demonstrated extend many hours vitro and several weeks vivo . It not known how LTP relates memory although there considerable evidence for the hypothesis that hippocampal involved memory. Regardless, it best understood example synaptic plasticity mammalian central nervous system (CNS), model memory-associated changes are likely occur CNS. Understanding will yield valid insights into mechanisms underlie learning brain. bona fide neuronal connections may or identical presently studied laboratory, but does diminish its utility cellular studying lasting