NF-κB Controls Cell Fate Specification, Survival, and Molecular Differentiation of Immunoregulatory Natural T Lymphocytes

摘要: Ontogenetic, homeostatic, and functional deficiencies within immunoregulatory natural T (iNKT) lymphocytes underlie various inflammatory immune disorders including autoimmunity. Signaling events that control cell fate specification molecular differentiation of iNKT cells are only partly understood. Here we demonstrate these processes require classical NF-κB signaling. Inhibition signaling blocks ontogeny at an immature stage reveals apparent, novel precursor in which negative selection occurs. Most importantly, this block occurs due to a lack survival signals, as Bcl-x L overexpression rescues ontogeny. Maturation precursors induces Bcl-2 expression, is defective the absence also maturation-induced expression. Thus, antiapoptotic signals relayed by critically and, hence, reveal role for such system.