Development and Selection of Vα14i NKT Cells
作者： H. R. MacDonald , M. P. Mycko
DOI: 10.1007/978-3-540-69511-0_8
关键词: Immunology 、 FYN 、 Natural killer T cell 、 T-cell receptor 、 Haematopoiesis 、 Cytokine 、 CD8 、 Cell biology 、 T lymphocyte 、 T cell 、 Biology
摘要: Valpha14 invariant natural killer T (Valpha14i NKT) cells are a unique lineage of mouse that share properties with both NK and memory cells. Valpha14i NKT recognize CDld-associated glycolipids via semi-invariant cell receptor (TCR) composed an Valpha14-Jalpha 18 chain paired preferentially restricted set TCRbeta chains. During development in the thymus, rare CD4+ CD8+ (DP) cortical thymocytes successfully rearrange TCR directed to interactions CD d-associated endogenous expressed by other DP thymocytes. As they mature, Valphal4i upregulate activation markers such as CD44 subsequently express NK-related molecules NKI.1 members Ly-49 inhibitory family. The developmental program Valpha l4i is critically regulated number signaling cues have little or no effect on conventional development, Fyn/SAP/SLAM pathway, NFkappaB T-bet transcription factors, cytokine IL-15. requirements may represent paradigm for unconventional subsets positively selected agonist ligands hematopoietic
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