Stearoyl-CoA desaturase-2 gene expression is required for lipid synthesis during early skin and liver development

摘要: There are four known stearoyl-CoA desaturase (SCD) enzyme isoforms in mouse and two humans that required for the biosynthesis of monounsaturated fatty acids, mainly oleate. SCD1 isoform plays a role regulation energy metabolism lipid synthesis, but roles other SCD have not been investigated. Here we show SCD2 is important synthesis early development survival. SCD2-deficient (Scd2-/-) neonatal mice skin permeability barrier defect specific repartitioning linoleic acid from epidermal acylceramide species into phospholipids. expression high liver wild-type embryos neonates between embryonic day 18.5 21 days age decreased adult mice. expression, on hand, induced after weaning. The liver, skin, plasma triglyceride contents altered Scd2-/- These results indicate that, although mice, crucial acids maintaining normal function lipids during development.