The therapeutic effect of vasoactive intestinal peptide on experimental arthritis is associated with CD4+CD25+ T regulatory cells.
作者： G. Chen , J. Hao , Y. Xi , W. Wang , Z. Wang
DOI: 10.1111/J.1365-3083.2008.02178.X
关键词: Immunology 、 Vasoactive intestinal peptide 、 Rheumatoid arthritis 、 Immune system 、 T cell 、 Experimental arthritis 、 In vivo 、 IL-2 receptor 、 Therapeutic effect 、 Medicine
摘要: Vasoactive intestinal peptide (VIP) has been found to act as a potent anti-inflammatory factor through regulating the production of both anti- and pro-inflammatory mediators promoting Th2-type responses. In this study, we used Chicken collagen II-induced experimental arthritis (CIA) model in Wistar rats investigate potential effects VIP on rheumatoid arthritis. Our results showed that vivo treatment CIA-induced with had great protective benefit at clinical histological levels. Disease suppression was associated inhibition T cells proliferation, shifting immune response toward expanded CD4+CD25+ Treg periphery, which inhibited autoreactive cell activation/expansion. conclusion, study provides evidence effect CIA its actions pathogenic cells.
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