Decreased antibody response to influenza vaccination in kidney transplant recipients: a prospective cohort study.

摘要: Background Antibody response to the inactivated influenza vaccine is not well described in kidney transplant recipients administered newer, but commonly used, immunosuppression medications. We hypothesized that recipient participants tacrolimus-based regimens would have decreased antibody compared with healthy controls. Study Design Prospective cohort study of 53 and 106 control during 2006-2007 season. All received standard vaccine. Setting & Participants Kidney at a single academic medical center Predictor Presence transplant. Outcomes Proportion achieving seroresponse (4-fold increase titer) seroprotection (antibody titer ≥ 1:32) 1 month after vaccination. Measurements titers before vaccination by means hemagglutinin inhibition assays for types A/H1N1, A/H3N2, B. Results A smaller proportion transplantation group developed primary outcomes or all 3 The type A/H3N2 was statistically different; had 69% odds developing (95% confidence interval, 0.16 0.62; P = 0.001) 78% 0.09 0.53; When less than 6 months from time were considered, this significantly Limitations Decreased sample size, potential confounders, outcome measure used does give information about efficacy. Conclusions recipients, especially within transplantation, diminished