Method for labeling oligonucleotide with ammonia-sensitive ligands
作者： Edge Renfeng Wang
DOI:
关键词: Cleavage (embryo) 、 Stereochemistry 、 Oligonucleotide 、 Ammonia 、 Combinatorial chemistry 、 Decomposition 、 Chemistry 、 Ligand
摘要: The invention provides method for labeling oligonucleotides and their analogs with ammonia-sensitive ligands. A non-ammonia cocktail is used cleavage deprotection in combination base labile linkers. process done on the solid phase cleaved by to prevent ligand from decomposition.
lens.org 参考文章(1)
Steven Fung, Steven M. Menchen, Sam L. Woo, Method of synthesizing oligonucleotides labeled with ammonia-labile groups on solid phase supports ,(1987)