Dissymetrisation de la molecule de glyoxal: II. Action des organometalliques sur l'acetoxy-1 triethoxy-1,2,2 ethane☆
作者： A. Stambouli , R. Amouroux , F. Chastrette , M. Chastrette , G. Mattioda
DOI: 10.1016/0022-328X(86)80467-3
关键词: Group 2 organometallic chemistry 、 Addition reaction 、 Lewis acids and bases 、 Acetal 、 Medicinal chemistry 、 Acetoxy group 、 Aldol reaction 、 Acylal 、 Chemistry 、 Glyoxal 、 Organic chemistry
摘要: Abstract Various organometallic compounds are treated with 1-acetoxy-1,2,2-triethoxyethane ( 1 ) an asymmetric derivative of glyoxal. Two kinds reactions observed depending on the nature reagents. Organolithium give exclusively addition to ester carbonyl group, while organocuprate derivatives lead substitution acetoxy group. With Grignard reagents both occur, proportion and products solvent alkyl The role Lewis acids is discussed.
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