Epidermolysis bullosa acquisita and bullous systemic lupus erythematosus. Diseases of autoimmunity to type VII collagen.

摘要: Autoimmunity to C7 is a genetically predisposed condition that results in the production of predominantly IgG class basement membrane autoantibodies may cause damage and subepidermal blisters by at least two pathogenic mechanisms. cuts across traditional disease classifications (EBA versus bullous SLE), presents with heterogeneous clinical pathologic features, mimics other diseases, be difficult diagnose treat. associated susceptibility SLE perhaps inflammatory bowel disease.