Protein and Bacterial Antifouling Behavior of Melt-Coextruded Nanofiber Mats
作者： Si-Eun Kim , Cong Zhang , Abigail A. Advincula , Eric Baer , Jonathan K. Pokorski
关键词: Materials science 、 Fiber 、 Biofouling 、 Composite material 、 Amphiphile 、 Methacrylate 、 Ethylene glycol 、 Secondary infection 、 Polymer 、 Nanofiber
摘要: Antifouling surfaces are important for biomedical devices to prevent secondary infections and mitigate the effects of foreign body response. Herein, we describe melt-coextruded poly(e-caprolactone) (PCL) nanofiber mats grafted with antifouling polymers. Nonwoven PCL fiber produced using a multilayered melt coextrusion process followed by high-pressure hydroentanglement yield porous patches. The resulting show submicrometer cross-sectional dimensions pore sizes that were nearly uniform, mean size 1.6 ± 0.9 μm. Several polymers, including hydrophilic, zwitterionic, amphipathic molecules, surface two-step procedure includes photochemistry copper-catalyzed azide–alkyne cycloaddition reaction. Fiber evaluated separate adsorption tests serum proteins E. coli. results indicate poly(oligo(ethylene glycol) methyl ether methacrylate)-co-(trifluoroethyl...
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