Methods and reagents for oligonucleotide synthesis

作者: Chandra Vargeese , Weimin Wang

DOI:

关键词: RNAReagentBiochemistryOligonucleotide synthesisOligonucleotideSolid-phase synthesisCombinatorial chemistryDNAChemistry

摘要: The present invention features novel compositions, linkers, derivatized solid supports, and methods for the efficient phase synthesis of oligonucleotides, including RNA, DNA, RNA-DNA chimeras, analogs thereof.

参考文章(117)
Andrew D. Ellington, Jack W. Szostak, 20 In Vitro Selection of Functional RNA Sequences Cold Spring Harbor Monograph Archive. ,vol. 24, pp. 511- 533 ,(1993) , 10.1101/087969380.24.511
H.H. Weetall, A.M. Filbert, Porous glass for affinity chromatography applications. Methods in Enzymology. ,vol. 34, pp. 59- 72 ,(1974) , 10.1016/S0076-6879(74)34007-4
Sun S, Technology evaluation: SELEX, Gilead Sciences Inc. Current Opinion in Molecular Therapeutics. ,vol. 2, pp. 100- ,(2000)
R. T. Pon, K. K. Ogilvie, Nassim Usman, Derivatization of controlled pore glass beads for solid phase oligonucleotide synthesis. BioTechniques. ,vol. 6, pp. 768- 775 ,(1988)
M.H. Caruthers, G. Beaton, J.V. Wu, W. Wiesler, Chemical synthesis of deoxyoligonucleotides and deoxyoligonucleotide analogs. Methods in Enzymology. ,vol. 211, pp. 3- 20 ,(1992) , 10.1016/0076-6879(92)11003-2
Jeffrey M. Bockman, Shaji T. George, Andy Shih, Ribozyme amplified diagnostics ,(1993)
Stanley T. Crooke, Progress in antisense technology: the end of the beginning. Methods in Enzymology. ,vol. 313, pp. 3- 45 ,(2000) , 10.1016/S0076-6879(00)13003-4
Nassim Usman, James A. McSwiggen, Chapter 30. Catalytic RNA (Ribozymes) as Drugs Annual Reports in Medicinal Chemistry. ,vol. 30, pp. 285- 294 ,(1995) , 10.1016/S0065-7743(08)60943-4
Brian Dr Sproat, Giovanni Dr Paolella, Angus Dr Lamond, Synthetic catalytic oligonucleotide structures ,(1992)