Synthetic catalytic oligonucleotide structures
作者： Brian Dr Sproat , Giovanni Dr Paolella , Angus Dr Lamond
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摘要: A b s t r a c synthetic catalytic oligonucleotide structure and nucleotides having the general structural formula (I) contains: in which B represents nucleoside base is particular selected from group comprising adenin-9-yl (A), cytosin-1-yl (C), guanin-9-yl (G), uracil-1-yl (U), uracil-5-yl (?), hypoxanthin-9-yl (I), thymin-1-yl (T) 2-aminoadenin-9-yl, V each nucleotide independently an O or CH2 group, X W can be same different are of other O, S, NH2, alkyl alkoxy groups with 1 to 10, preferably 4 carbon atoms, R hydrogen straight-chained branched alkyl, alkenyl alkinyl 10 atoms substituted, if desired, halogen, cyano, isocyano, nitro, amino, carboxyl, hydroxyl or/and mercapto groups, at least one residue suitable for cleavage nucleic acid target sequence.
google.co.id参考文章(8)
Nanibhushan Dattagupta, Nucleic acid amplification employing transcribable hairpin probe ,(1990)
Nanibhushan Dattagupta, Nucleic acid amplification employing ligatable hairpin probe and transcription ,(1990)
Brian S. Sproat, Barbro Beijer, Adolfo Iribarren, New synthetic routes to protected purine 2′-O-methylriboside-3′-O-phosphoramidites using a novel alkylation procedure Nucleic Acids Research. ,vol. 18, pp. 41- 49 ,(1990) , 10.1093/NAR/18.1.41
Cheryl J. Hutchins, Peter D. Rathjen, Anthony C. Forster, Robert H. Symons, Self-cleavage of plus and minus RNA transcripts of avocado sunblotch viroid Nucleic Acids Research. ,vol. 14, pp. 3627- 3640 ,(1986) , 10.1093/NAR/14.9.3627
Brian S. Sproat, Adolfo M. Iribarre, Ramon Guimil Garcia, Barbro Beijer, New synthetic routes to synthons suitable for 2′-O-allyloligoribonucleotide assembly Nucleic Acids Research. ,vol. 19, pp. 733- 738 ,(1991) , 10.1093/NAR/19.4.733
Paul O. P. Ts'o, Paul S. Miller, Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof ,(1980)
Margaret F. Hicks, Arnold E. Hampel, Richard H. Tritz, RNA catalyst for cleaving specific RNA sequences ,(1989)
Arnold Hampel, Richard Tritz, Margaret Hicks, Phillip Cruz, ‘Hairpin’ catalytic RNA model: evidence for helices and sequence requirement for substrate RNA Nucleic Acids Research. ,vol. 18, pp. 299- 304 ,(1990) , 10.1093/NAR/18.2.299