Anti-viral guanosine-rich oligonucleotides and method of treating HIV
作者： Joseph G. Zendegui , Susan Fennewald , Joshua O. Ojwang , Michael E. Hogan , Robert F. Rando
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摘要: A method and compositions for treating viral infection in vitro vivo using a guanosine-rich oligonucleotide. The oligonucleotides have sufficient guanosine to form tetrad. Also provided are of at least two runs guanosines. methods infections humans, designing having anti-viral activity integrase inhibition activity.
lens.org参考文章(36)
A. Kirk Field, Alfred A. Tytell, George P. Lampson, Pharmaceutical composition comprising modified polyriboinosinic-polyribocytidylic acid, for induction of interferon in primates ,(1980)
K Nagy, M Young, C Baboonian, J Merson, P Whittle, S Oroszlan, Antiviral activity of human immunodeficiency virus type 1 protease inhibitors in a single cycle of infection: evidence for a role of protease in the early phase. Journal of Virology. ,vol. 68, pp. 757- 765 ,(1994) , 10.1128/JVI.68.2.757-765.1994
Brian Dr Sproat, Giovanni Dr Paolella, Angus Dr Lamond, Synthetic catalytic oligonucleotide structures ,(1992)
Y S He, L Xu, E S Huang, Characterization of human cytomegalovirus UL84 early gene and identification of its putative protein product. Journal of Virology. ,vol. 66, pp. 1098- 1108 ,(1992) , 10.1128/JVI.66.2.1098-1108.1992
J C Tamashiro, D Filpula, T Friedmann, D H Spector, Structure of the heterogeneous L-S junction region of human cytomegalovirus strain AD169 DNA. Journal of Virology. ,vol. 52, pp. 541- 548 ,(1984) , 10.1128/JVI.52.2.541-548.1984
Michael Daniel Cahalan, Stephen Grissmer, Kanianthara George Chandy, Assay for and treatment of autoimmune diseases ,(1990)
Gerald Zon, Oligonucleotide Analogues as Potential Chemotherapeutic Agents Pharmaceutical Research. ,vol. 5, pp. 539- 549 ,(1988) , 10.1023/A:1015985728434
Eugen Dr. Uhlmann, Anuschirwan Dr. Peyman, G cap-stabilized oligonucleotides ,(1996)
R D Rasmussen, S I Staprans, S B Shaw, D H Spector, Sequences in human cytomegalovirus which hybridize with the avian retrovirus oncogene v-myc are G + C rich and do not hybridize with the human c-myc gene. Molecular and Cellular Biology. ,vol. 5, pp. 1525- 1530 ,(1985) , 10.1128/MCB.5.6.1525