Chondrogenic Progenitors for Cartilage Repair and Osteoarthritis

摘要: disease may alter endogenous progenitor populations and compromise their ability to accomplish self-repair. Consistent with this possibility, mesenchymal progenitors isolated from osteoarthritic cartilage underwent spontaneous osteogenic differentiation in vitro which was not observed normal adult [11]. It is also possible that progenitors, particularly the highly migratory cells associated vascular invasion osteoarthritis, be part of a response damage aimed provide temporary rather than permanent repair. For instance, surgical procedures such as micro fracture, allow subchondral bone marrow enter articular cartilage, result formation fibro hyaline [12]. The chondrogenic potential stem further compromised by donor age [13]. Alterations local environment joint reduce progenitors. High levels inflammatory cytokines are present or acutely injured joints, treatment diseased synovial fluid reduces [14,15].