Therapeutic approaches in the management of locally advanced rectal cancer
作者： Simon D. Fung-Kee-Fung
DOI: 10.3978/J.ISSN.2078-6891.2014.067
关键词: Medicine 、 Neoadjuvant therapy 、 Concurrent chemotherapy 、 Radiation therapy 、 Locally advanced 、 Combined Modality Therapy 、 Colorectal cancer 、 Adjuvant chemotherapy 、 Intensive care medicine 、 Chemotherapy
摘要: Combined-modality therapy, using radiotherapy and chemotherapy with surgery, has been the traditional therapeutic algorithm for locally advanced rectal cancer. Standard of care in United States evolved to include neoadjuvant concurrent followed by surgical excision adjuvant chemotherapy. This approach led a significant improvement local recurrences (LR), point where distant sites are more common site failure. Further improvements control have failed improve overall survival. article reviews historical trials that shifted treatment paradigm current standard care, as well recent research trials, which sought incorporate new methodologies, agents outcomes. Finally this describes ongoing studies their potential impact on future management locally-advanced
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