Rearrangement of the Dendritic Morphology of the Neurons From Prefrontal Cortex and Hippocampus After Subthalamic Lesion in Sprague-Dawley Rats

摘要: KEY WORDS subthalamic nucleus; dendritic morphology; prefrontal cortex; hippo-campus; nucleus accumbens; Parkinson’s diseaseABSTRACT Several studies in rodents have suggested the inactivation of sub-thalamic (STN) as an alternative strategy to disease (PD) treat-ment. The STN is part basal ganglia and plays important role motorfunction; however, recent data suggest that this structure has a critical cog-nitive function limbic system. receives direct projection from pre-frontal cortex (PFC), interconnected with hippocampus bothstructures send excitatory projections accumbens (NAcc). Here, wedetermined whether which changes occurred 4 weeks after lesion thedendritic morphology pyramidal neurons layers 3 5 PFC baso-lateral amygdala, ventral hippocampus, medium spiny neuronsof NAcc caudate-putamen. Dendritic was measured using theGolgi-Cox procedure followed by Sholl analysis. We also evaluated effects STNlesion on locomotor behavior assessed open field test, social interaction, acousticstartle response, prepulse inhibition, activity induced novel envi-ronment amphetamine. found damage deficit locomo-tion test neuronal hypertrophy (layer 5)and reduced spinogenesis CA1 3). Takentogether, these behavioral morphological are, at least partially, mediated subregions possible consequencesfor cognitive-related behaviors observed PD treatment. Synapse 68:114–126, 2014.