Rate of virologic failure and selection of drug resistance mutations using different triple nucleos(t)ide analogue combinations in HIV-infected patients.
作者： Luz Martín-Carbonero , Paldma Gil , Teresa García-Benayas , Pablo Barreiro , Francisco Blanco
关键词: Virology 、 Nucleoside analogue 、 Gastroenterology 、 Internal medicine 、 Sida 、 Viral disease 、 Biology 、 Drug resistance 、 Drug-naïve 、 Reverse transcriptase 、 Viremia 、 Viral load
摘要: Virologic failure seems to occur more frequently in HIV-infected patients treated with triple nucleoside analogue (NA) combinations than regimens including nonnucleoside reverse transcriptase inhibitors or protease inhibitors. However, the rate of and resistance profiles may differ distinct NA combinations. A retrospective review all individuals who received at our institution was conducted. defined as lack achievement plasma HIV-RNA <50 copies/ml week 16 following initiation antiretroviral therapy viral rebound subjects prior undetectable viremia. Genotypic analyses were performed time first virological failure. Of 261 identified, 13 drug naive, 126 had underwent simplification, 122 antiretroviral-experienced detectable load. recorded 95 (36.4%) after an average follow-up 19 months. Rates 0.67 drug-naiv...
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