Treatment of Grade 3 and 4 Osteoarthritis with Intraoperatively Separated Adipose Tissue-Derived Stromal Vascular Fraction: A Comparative Case Series.
作者： Denis Simunec , Honey Salari , Juliane Meyer
DOI: 10.3390/CELLS9092096
关键词: Osteoarthritis 、 Adipose tissue 、 Arthritis 、 Cartilage 、 Stromal vascular fraction 、 Magnetic resonance imaging 、 Joint replacement 、 Population 、 Medicine 、 Surgery
摘要: Osteoarthritis (OA) is the most common form of arthritis joints. The stromal vascular fraction (SVF) a regenerative cell population that can be isolated from adipose tissue. It immunomodulatory properties make it promising candidate for treatment OA. Patients with grade 3 and 4 osteoarthritis were treated without platelet-rich plasma (PRP) followed up on their Knee Injury Outcome Score (KOOS) score 12 months, MRI subjective evaluation procedure. Magnetic resonance imaging (MRI) revealed widening joint space, restructuring cartilage, an alleviation effusions in In three four groups, substantial improvement KOOS scores was documented at 12-month follow-up time point. According to evaluation, 67% patients satisfied or very procedure would recommend others. No serious adverse events unwanted side effects related SVF observed reported. Prior invasive artificial replacement, arthritic knee joints intraarticular injection autologous tissue-derived should considered option.
mdpi.com
sci-hub.st 参考文章(28)
Chris Hyunchul Jo, Young Gil Lee, Won Hyoung Shin, Hyang Kim, Jee Won Chai, Eui Cheol Jeong, Ji Eun Kim, Hackjoon Shim, Ji Sun Shin, Il Seob Shin, Jeong Chan Ra, Sohee Oh, Kang Sup Yoon, Intra‐Articular Injection of Mesenchymal Stem Cells for the Treatment of Osteoarthritis of the Knee: A Proof‐of‐Concept Clinical Trial Stem Cells. ,vol. 32, pp. 1254- 1266 ,(2014) , 10.1002/STEM.1634
Yong-Gon Koh, Yun-Jin Choi, Sae-Kwang Kwon, Yong-Sang Kim, Jee-Eun Yeo, Clinical results and second-look arthroscopic findings after treatment with adipose-derived stem cells for knee osteoarthritis Knee Surgery, Sports Traumatology, Arthroscopy. ,vol. 23, pp. 1308- 1316 ,(2015) , 10.1007/S00167-013-2807-2
Julie A. Semon, Xiujuan Zhang, Amitabh C. Pandey, Sandra M. Alandete, Catherine Maness, Shijia Zhang, Brittni A. Scruggs, Amy L. Strong, Steven A. Sharkey, Marc M. Beuttler, Jeffrey M. Gimble, Bruce A. Bunnell, Administration of Murine Stromal Vascular Fraction Ameliorates Chronic Experimental Autoimmune Encephalomyelitis Stem Cells Translational Medicine. ,vol. 2, pp. 789- 796 ,(2013) , 10.5966/SCTM.2013-0032
Agnieszka S. Klar, Sinan Güven, Thomas Biedermann, Joachim Luginbühl, Sophie Böttcher-Haberzeth, Claudia Meuli-Simmen, Martin Meuli, Ivan Martin, Arnaud Scherberich, Ernst Reichmann, Tissue-engineered dermo-epidermal skin grafts prevascularized with adipose-derived cells. Biomaterials. ,vol. 35, pp. 5065- 5078 ,(2014) , 10.1016/J.BIOMATERIALS.2014.02.049
Chiara Chiellini, Olivia Cochet, Luc Negroni, Michel Samson, Marjorie Poggi, Gérard Ailhaud, Marie-Christine Alessi, Christian Dani, Ez-Zoubir Amri, Characterization of human mesenchymal stem cell secretome at early steps of adipocyte and osteoblast differentiation. BMC Molecular Biology. ,vol. 9, pp. 26- 26 ,(2008) , 10.1186/1471-2199-9-26
Lindolfo da Silva Meirelles, Arnold I. Caplan, Nance Beyer Nardi, In search of the in vivo identity of mesenchymal stem cells Stem Cells. ,vol. 26, pp. 2287- 2299 ,(2008) , 10.1634/STEMCELLS.2007-1122
James Guo, Andrew Nguyen, Derek A. Banyard, Darya Fadavi, Jason D. Toranto, Garrett A. Wirth, Keyianoosh Z. Paydar, Gregory R.D. Evans, Alan D. Widgerow, Stromal vascular fraction: A regenerative reality? Part 2: Mechanisms of regenerative action. Journal of Plastic Reconstructive and Aesthetic Surgery. ,vol. 69, pp. 180- 188 ,(2016) , 10.1016/J.BJPS.2015.10.014
Patricia A. Zuk, Min Zhu, Peter Ashjian, Daniel A. De Ugarte, Jerry I. Huang, Hiroshi Mizuno, Zeni C. Alfonso, John K. Fraser, Prosper Benhaim, Marc H. Hedrick, Human Adipose Tissue Is a Source of Multipotent Stem Cells Molecular Biology of the Cell. ,vol. 13, pp. 4279- 4295 ,(2002) , 10.1091/MBC.E02-02-0105
Neil H Riordan, Thomas E Ichim, Wei-Ping Min, Hao Wang, Fabio Solano, Fabian Lara, Miguel Alfaro, Jorge Rodriguez, Robert J Harman, Amit N Patel, Michael P Murphy, Roland R Lee, Boris Minev, Non-expanded adipose stromal vascular fraction cell therapy for multiple sclerosis Journal of Translational Medicine. ,vol. 7, pp. 29- 29 ,(2009) , 10.1186/1479-5876-7-29
W. Zhang, G. Nuki, R.W. Moskowitz, S. Abramson, R.D. Altman, N.K. Arden, S. Bierma-Zeinstra, K.D. Brandt, P. Croft, M. Doherty, M. Dougados, M. Hochberg, D.J. Hunter, K. Kwoh, L.S. Lohmander, P. Tugwell, OARSI recommendations for the management of hip and knee osteoarthritis: part III: Changes in evidence following systematic cumulative update of research published through January 2009 Osteoarthritis and Cartilage. ,vol. 18, pp. 476- 499 ,(2010) , 10.1016/J.JOCA.2010.01.013