Effect of NG-nitro-L-arginine methyl ester on the hypotensive and hypertensive responses to 5-hydroxytryptamine in pithed rats

摘要: Abstract The potential ability of the nitric oxide (NO) synthase inhibitor, N G -nitro-L-arginine methyl ester (L-NAME; 1 to 10 mg/kg), modulate blood pressure responses 5-hydroxytryptamine (5-HT), 5-carboxamidotryptamine (5-CT) and (1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) was studied in pithed rats. hypotensive 5-HT presence ketanserin were augmented by L-NAME as well phenylonhrine infusion, both which themselves increased pressure. also tended prolong duration response 5-HT. Likewise, 5-CT potentiated. magnitude hypertensive unaffected or phenylephrine. However, contrast phenylephrine, prolonged these responses. (middle dose only) DOI L-NAME, but phenylephrine ineffective. These results suggest that increases pressure, probably inhibiting basal release NO animals with a low vascular tone. seem be largely independent endothelium, appear limited rat.