The effects of NG-nitro-L-arginine methyl ester on systolic pressure, diastolic pressure and pulse pressure according to the initial level of blood pressure.

摘要: The objective of this study was to re-examine whether the effect nitric oxide synthesis inhibitor, N(G)-nitro-L-arginine methyl ester (L-NAME), on blood pressure depends peripheral vascular tone. effects L-NAME (10 mg/kg, i.v.) diastolic (DBP), systolic (SBP), pulse (PP) and heart rate (HR) were studied in pithed rats. Sal-pithed rats received 0.9% NaCl, 10 microl/kg/min. Vascular tone step-wise increased with 3, 30 microg/kg/min intravenous phenylephrine infusion (LPhe-pithed, MPhe-pithed HPhe-pithed respectively). elicited vasopressor responses all animals studied. increases SBP DBP significantly smaller than ones obtained infused by greater LPhe-pithed compared those (i.e. rises inversely related produced L-NAME); however, similar between these experimental groups. PP during L-NAME-induced pressor phenylephrine-infused l-NAME showed following order: < or = HR not modified L-NAME. In conclusion, are influenced pre-existing vasomotor complex form. We did find a simple positive correlation level arterial pressure, magnitude Interestingly, increase induced accordance increasing value baseline pressure. NO inhibition endothelium may possibly explain caused L-NAME, as resulting from reduction proximal conduit artery compliance.