To Go Against Nature: Manipulating the Neonatal Ductus Arteriosus with Prostaglandin

摘要: Abstract First observed by two gynecologists, Kurzrok and Lieb, a substance found in semen was named prostaglandin VonEuler of the Karolinska Institute, with assumption that it produced prostate gland ( Clin Perinatol . 1995;22:457–477). Endogenous prostaglandins PGE 2 I are within ductus arteriosus lumen during gestation to keep patent Semin 1987;11:64–71). Practitioners can prolong patency neonates ductal-dependent congenital heart defects through use injectable prostaglandin. In 1981, Food Drug Administration approved Alprostadil, E 1 , for treatment disease Intell Pharm 1982;16:823–832). This article will review role intrauterine extrauterine life, as well pharmacology, adverse effects, drug interactions, nursing implications associated use.