THE DIAGNOSTIC VALUE OF SERUM CREATINE KINASE IN NEUROMUSCULAR AND MUSCULAR DISEASE

摘要: Serum creatine kinase activity in 200 patients was studied order to check whether this determination might be of help differential diagnosis between primary and secondary (neurogenic) myopathies. Elevated CK values are found physiologically children, pregnant women, after exercise. In pathological states increased serum enzyme concentrations (probably the expression a defect cellular permeability) constantly present Duchenne type progressive muscular dystrophy. More variable encountered other types dystrophy metabolic disorders like Refsum9s syndrome, coproporphyria, hypothyroidism. necrosis or injury muscle cells polymyositis, dermatomyositis, burns trauma, vary according partly amount mass involved. Enzyme can markedly tetany epileptic seizures. Normal occasionally slightly neurogenic High with atrophies should permit clinician exclude diagnostic group As tool proved more reliable than transaminases lactic dehydrogenase because its higher specificity greater sensitivity.