Cancer Cell Death-Inducing Radiotherapy: Impact on Local Tumour Control, Tumour Cell Proliferation and Induction of Systemic Anti-tumour Immunity.

摘要: Radiotherapy (RT) predominantly is aimed to induce DNA damage in tumour cells that results reduction of their clonogenicity and finally cell death. Adaptation RT with higher single doses has become necessary led a more detailed view on what kind death induced which immunological consequences result from it. capable rendering immunogenic by modifying the phenotype microenvironment. Danger signals are released as well senescence-associated secretory phenotype. This maturation dendritic priming cytotoxic T activation natural killer cells. However, other hand can also immune suppressive events including apoptosis induction foster proliferation. That's why nowadays increasingly combined selected immunotherapies.