Macrophage polarisation changes within the time between diagnostic biopsy and tumour resection in oral squamous cell carcinomas--an immunohistochemical study.
作者： M Weber , P Moebius , M Büttner-Herold , K Amann , R Preidl
DOI: 10.1038/BJC.2015.212
关键词:
摘要: The prognosis of solid malignancies has been shown to depend on immunological parameters, such as macrophage polarisation (M1/M2). Recently, it was reported that preoperative oral surgery leads a worsening squamous cell carcinomas (OSCC) prognosis. Diagnostic incision biopsies are procedures might lead healing-associated M2 with potential negative influence tumour biology. No studies have compared in OSCC and specimens. Preoperative diagnostic (n=25) resection specimens (n=34) T1/T2 were processed for immunohistochemistry detect CD68-, CD11c-, CD163- MRC1-positive cells. Samples digitised using whole-slide imaging, the expression markers quantitatively analysed. Carcinoma tissues obtained during resections showed significantly (P<0.05) increased CD163 count (M2 macrophages) biopsies. Additionally, CD163/CD68 ratio (an indicator polarisation) higher than This study revealed first time an increase samples biopsy-induced tissue trauma explain observed shift towards tumour-promoting type could accelerated progression.
nature.com
sci-hub.se 参考文章(47)
Xiaoguang Cao, Defen Shen, Mrinali M. Patel, Jingsheng Tuo, T. Mark Johnson, Timothy W. Olsen, Chi-Chao Chan, Macrophage polarization in the maculae of age-related macular degeneration: A pilot study Pathology International. ,vol. 61, pp. 528- 535 ,(2011) , 10.1111/J.1440-1827.2011.02695.X
Alberto Mantovani, Subhra K Biswas, Maria Rosaria Galdiero, Antonio Sica, Massimo Locati, Macrophage plasticity and polarization in tissue repair and remodelling The Journal of Pathology. ,vol. 229, pp. 176- 185 ,(2013) , 10.1002/PATH.4133
Yoichiro Hirata, Minoru Tabata, Hirotsugu Kurobe, Tatsuo Motoki, Masashi Akaike, Chika Nishio, Mayuko Higashida, Hiroaki Mikasa, Yutaka Nakaya, Shuichiro Takanashi, Takashi Igarashi, Tetsuya Kitagawa, Masataka Sata, Coronary Atherosclerosis Is Associated With Macrophage Polarization in Epicardial Adipose Tissue Journal of the American College of Cardiology. ,vol. 58, pp. 248- 255 ,(2011) , 10.1016/J.JACC.2011.01.048
Manuel Weber, Maike Büttner-Herold, Peter Hyckel, Patrick Moebius, Luitpold Distel, Jutta Ries, Kerstin Amann, Friedrich W. Neukam, Falk Wehrhan, Small oral squamous cell carcinomas with nodal lymphogenic metastasis show increased infiltration of M2 polarized macrophages – An immunohistochemical analysis Journal of Cranio-maxillofacial Surgery. ,vol. 42, pp. 1087- 1094 ,(2014) , 10.1016/J.JCMS.2014.01.035
Falk Wehrhan, Maike Büttner-Herold, Peter Hyckel, Patrick Moebius, Raimund Preidl, Luitpold Distel, Jutta Ries, Kerstin Amann, Christian Schmitt, Friedrich W Neukam, Manuel Weber, Increased malignancy of oral squamous cell carcinomas (oscc) is associated with macrophage polarization in regional lymph nodes - an immunohistochemical study. BMC Cancer. ,vol. 14, pp. 522- 522 ,(2014) , 10.1186/1471-2407-14-522
Paul H. Lange, Kiumars Hekmat, George Bosl, B. J. Kennedy, Elwin E. Fraley, Accelerated Growth of Testicular Cancer after Cytoreductive Surgery Cancer. ,vol. 45, pp. 1498- 1506 ,(1980) , 10.1002/1097-0142(19800315)45:6<1498::AID-CNCR2820450633>3.0.CO;2-7
Atsushi Anzai, Toshihisa Anzai, Shigenori Nagai, Yuichiro Maekawa, Kotaro Naito, Hidehiro Kaneko, Yasuo Sugano, Toshiyuki Takahashi, Hitoshi Abe, Satsuki Mochizuki, Motoaki Sano, Tsutomu Yoshikawa, Yasunori Okada, Shigeo Koyasu, Satoshi Ogawa, Keiichi Fukuda, Regulatory Role of Dendritic Cells in Postinfarction Healing and Left Ventricular Remodeling Circulation. ,vol. 125, pp. 1234- 1245 ,(2012) , 10.1161/CIRCULATIONAHA.111.052126
Katsuya Ohtake, Susumu Shingaki, Tamio Nakajima, Effects of incision and irradiation on regional lymph node metastasis in carcinoma of the hamster tongue Oral Surgery, Oral Medicine, Oral Pathology. ,vol. 70, pp. 62- 69 ,(1990) , 10.1016/0030-4220(90)90180-Z
Christopher J. O'Brien, Christopher S. Lauer, Susanne Fredricks, Anthony R. Clifford, Edward B. McNeil, Jai S. Bagia, Christina Koulmandas, Tumor thickness influences prognosis of T1 and T2 oral cavity cancer--but what thickness? Head and Neck-journal for The Sciences and Specialties of The Head and Neck. ,vol. 25, pp. 937- 945 ,(2003) , 10.1002/HED.10324
AE Bogden, J-P Moreau, PA Eden, Proliferative response of human and animal tumours to surgical wounding of normal tissues: onset, duration and inhibition. British Journal of Cancer. ,vol. 75, pp. 1021- 1027 ,(1997) , 10.1038/BJC.1997.175