Coronary Atherosclerosis Is Associated With Macrophage Polarization in Epicardial Adipose Tissue
作者： Yoichiro Hirata , Minoru Tabata , Hirotsugu Kurobe , Tatsuo Motoki , Masashi Akaike
DOI: 10.1016/J.JACC.2011.01.048
关键词:
摘要: Objectives The purpose of this report was to assess the link between macrophage polarization in epicardial adipose tissue and atherosclerosis patients with coronary artery disease (CAD). Background Macrophage accumulation enhances chronic inflammation tissue, but phenotypic change human its role atherogenesis are unknown. Methods Samples were obtained from subcutaneous during elective cardiac surgery (CAD, n = 38; non-CAD, 40). Infiltration M1/M2 macrophages investigated by immunohistochemical staining antibodies against CD11c CD206, respectively. Expression pro- anti-inflammatory adipocytokines evaluated real-time quantitative polymerase chain reaction. Results expression cytokines enhanced fat CAD compared that non-CAD (p Conclusions ratio is changed patients. Human associated tissue.
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