Expression of NLRP3 in subcutaneous adipose tissue is associated with coronary atherosclerosis
作者： Sachiko Bando , Daiju Fukuda , Takeshi Soeki , Sachiko Nishimoto , Etsuko Uematsu
DOI: 10.1016/J.ATHEROSCLEROSIS.2015.07.043
关键词:
摘要: Abstract Objectives The promotion of adipose tissue inflammation by lifestyle-related diseases such as obesity and diabetes accelerates atherogenesis; however, the underlying mechanisms remain incompletely understood. Nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3 (NLRP3) inflammasome contributes to chronic in tissue. Here, we investigated link between NLRP3 expression subcutaneous (SAT) severity coronary atherosclerosis. Methods results SAT was obtained from 72 patients who underwent heart device implantation angiography. Expression inflammasome-related molecules (NLRP3, IL-1β IL-18) were evaluated quantitative RT-PCR. Laboratory markers related measured. Patients with obesity, dyslipidemia (P Conclusions SAT, which is affected diseases, associated Our suggest that may have a role atherogenesis.
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