Nitrate in drinking water and colorectal cancer risk: A nationwide population-based cohort study.
作者： Jörg Schullehner , Birgitte Hansen , Malene Thygesen , Carsten B. Pedersen , Torben Sigsgaard
DOI: 10.1002/IJC.31306
关键词: Exposure assessment 、 Proportional hazards model 、 Water quality 、 Nitrate 、 Environmental health 、 Hazard ratio 、 Epidemiology 、 Population 、 Cohort study 、 Medicine
摘要: Nitrate in drinking water may increase risk of colorectal cancer due to endogenous transformation into carcinogenic N‐nitroso compounds. Epidemiological studies are few and often challenged by their limited ability of estimating long‐term exposure on a detailed individual level. We exploited population‐based health register data, linked in time and space with longitudinal drinking water quality data, on an individual level to study the association between long‐term drinking water nitrate exposure and colorectal cancer (CRC) …
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