Mutations in the heme b-binding residue of SDHC inhibit assembly of respiratory chain complex II in mammalian cells.
作者： Anthony Lemarie , Stefan Grimm
DOI: 10.1016/J.MITO.2009.03.004
关键词: Heme binding 、 Succinate dehydrogenase 、 Protein subunit 、 Biochemistry 、 SDHD 、 SDHB 、 Respiratory chain 、 Heme B 、 Heme 、 Biology
摘要: Respiratory chain complex II has been extensively studied but little is known about its assembly and the role of heme group. Mutations in phylogenetically conserved histidine 127 SDHC subunit have shown to abrogate binding yeast bacteria without impairing or enzymatic activities. Here we show that mammalian cells these mutations lead a complete reduction mitochondria, destabilisation SDHD SDHB, an abrogation activities, suggesting more than lower organisms.
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sci-hub.se 参考文章(31)
Mahin D. Maines, Current protocols in toxicology John Wiley. ,(1999)
Andreas Gewies, Stefan Grimm, UBP41 Is a Proapoptotic Ubiquitin-specific Protease Cancer Research. ,vol. 63, pp. 682- 688 ,(2003)
L Yu, J X Xu, P E Haley, C A Yu, Properties of bovine heart mitochondrial cytochrome b560. Journal of Biological Chemistry. ,vol. 262, pp. 1137- 1143 ,(1987) , 10.1016/S0021-9258(19)75761-5
Stephan Niemann, Ulrich Müller, Mutations in SDHC cause autosomal dominant paraganglioma, type 3. Nature Genetics. ,vol. 26, pp. 268- 270 ,(2000) , 10.1038/81551
K Kita, C R Vibat, S Meinhardt, J R Guest, R B Gennis, One-step purification from Escherichia coli of complex II (succinate: ubiquinone oxidoreductase) associated with succinate-reducible cytochrome b556. Journal of Biological Chemistry. ,vol. 264, pp. 2672- 2677 ,(1989) , 10.1016/S0021-9258(19)81666-6
A Lombardo, I E Scheffler, Isolation and characterization of a Saccharomyces cerevisiae mutant with a disrupted gene for the IP subunit of succinate dehydrogenase Journal of Biological Chemistry. ,vol. 264, pp. 18874- 18877 ,(1989) , 10.1016/S0021-9258(19)47237-2
Jean-Pierre Bayley, Peter Devilee, Peter EM Taschner, The SDH mutation database: an online resource for succinate dehydrogenase sequence variants involved in pheochromocytoma, paraganglioma and mitochondrial complex II deficiency BMC Medical Genetics. ,vol. 6, pp. 39- 39 ,(2005) , 10.1186/1471-2350-6-39
Jiri Neuzil, Jeffrey C. Dyason, Ruth Freeman, Lan-Feng Dong, Lubomir Prochazka, Xiu-Fang Wang, Immo Scheffler, Stephen J. Ralph, Mitocans as anti-cancer agents targeting mitochondria: lessons from studies with vitamin E analogues, inhibitors of complex II Journal of Bioenergetics and Biomembranes. ,vol. 39, pp. 65- 72 ,(2007) , 10.1007/S10863-006-9060-Z
Anne-Paule Gimenez-Roqueplo, Judith Favier, Pierre Rustin, Jean-Jacques Mourad, Pierre-François Plouin, Pierre Corvol, Agnès Rötig, Xavier Jeunemaitre, The R22X Mutation of the SDHD Gene in Hereditary Paraganglioma Abolishes the Enzymatic Activity of Complex II in the Mitochondrial Respiratory Chain and Activates the Hypoxia Pathway American Journal of Human Genetics. ,vol. 69, pp. 1186- 1197 ,(2001) , 10.1086/324413
Kayode S. Oyedotun, Clarissa S. Sit, Bernard D. Lemire, The Saccharomyces cerevisiae succinate dehydrogenase does not require heme for ubiquinone reduction. Biochimica et Biophysica Acta. ,vol. 1767, pp. 1436- 1445 ,(2007) , 10.1016/J.BBABIO.2007.09.008