Metformin Inhibits Growth of Human Glioblastoma Cells and Enhances Therapeutic Response
作者： Julie Sesen , Perrine Dahan , Sarah J. Scotland , Estelle Saland , Van-Thi Dang
DOI: 10.1371/JOURNAL.PONE.0123721
关键词: AMPK 、 Temozolomide 、 PI3K/AKT/mTOR pathway 、 Metformin 、 Biguanide 、 Programmed cell death 、 Cell growth 、 Internal medicine 、 Glioma 、 Biology 、 Endocrinology 、 Cancer research
摘要: … We also demonstrate that metformin could act as a GB cell sensitizer/enhancer for TMZ treatment and/or radiotherapy. Introducing this promising new form of treatment may lead to an …
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