Quantification of metformin by the HPLC method in brain regions, cerebrospinal fluid and plasma of rats treated with lipopolysaccharide
作者： Krzysztof Łabuzek , Dariusz Suchy , Bożena Gabryel , Anna Bielecka , Sebastian Liber
DOI: 10.1016/S1734-1140(10)70357-1
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摘要: Recently, it has been reported that metformin may attenuate inflammation and directly act on the central nervous system. Using HPLC method, in Wistar rats, we assessed changes concentrations various brain regions (pituitary gland, olfactory bulb, hypothalamus, cerebellum, hippocampus, striatum, frontal cortex), cerebrospinal fluid plasma after single chronic oral administration, model of systemic induced by lipopolysaccharide (ip). Regarding influence distribution, pituitary gland demonstrated highest its level administration (28.8 ± 3.5 nmol/g 24.9 3.2 nmol/g, respectively). We concluded orally-dosed rapidly crosses blood-brain barrier differently accumulates structures
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Narender Nath, Musfiquidin Khan, Manjeet K. Paintlia, Md Nasrul Hoda, Shailendra Giri, Metformin Attenuated the Autoimmune Disease of the Central Nervous System in Animal Models of Multiple Sclerosis Journal of Immunology. ,vol. 182, pp. 8005- 8014 ,(2009) , 10.4049/JIMMUNOL.0803563
GT Tucker, C Casey, PJ Phillips, H Connor, JD Ward, HF Woods, Metformin kinetics in healthy subjects and in patients with diabetes mellitus. British Journal of Clinical Pharmacology. ,vol. 12, pp. 235- 246 ,(1981) , 10.1111/J.1365-2125.1981.TB01206.X
Ramesh Saeedi, Hannah L. Parsons, Richard B. Wambolt, Kim Paulson, Vijay Sharma, Jason R. B. Dyck, Roger W. Brownsey, Michael F. Allard, Metabolic actions of metformin in the heart can occur by AMPK-independent mechanisms American Journal of Physiology-heart and Circulatory Physiology. ,vol. 294, ,(2008) , 10.1152/AJPHEART.00873.2007
Alejandro Vazquez-Martin, Cristina Oliveras-Ferraros, Javier A. Menendez, The antidiabetic drug metformin suppresses HER2 (erbB-2) oncoprotein overexpression via inhibition of the mTOR effector p70S6K1 in human breast carcinoma cells. Cell Cycle. ,vol. 8, pp. 88- 96 ,(2009) , 10.4161/CC.8.1.7499
Thong C. Ma, Jessica L. Buescher, Benjamin Oatis, Jason A. Funk, Andrew J. Nash, Raeann L. Carrier, Kari R. Hoyt, Metformin therapy in a transgenic mouse model of Huntington's disease Neuroscience Letters. ,vol. 411, pp. 98- 103 ,(2007) , 10.1016/J.NEULET.2006.10.039
Marie E Beckner, Glenn T Gobbel, Roger Abounader, Fatima Burovic, Naomi R Agostino, John Laterra, Ian F Pollack, Glycolytic glioma cells with active glycogen synthase are sensitive to PTEN and inhibitors of PI3K and gluconeogenesis. Laboratory Investigation. ,vol. 85, pp. 1457- 1470 ,(2005) , 10.1038/LABINVEST.3700355
Y. Chen, K. Zhou, R. Wang, Y. Liu, Y.-D. Kwak, T. Ma, R. C. Thompson, Y. Zhao, L. Smith, L. Gasparini, Z. Luo, H. Xu, F.-F. Liao, Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription Proceedings of the National Academy of Sciences of the United States of America. ,vol. 106, pp. 3907- 3912 ,(2009) , 10.1073/PNAS.0807991106
S. AbuRuz, J. Millership, J. McElnay, The development and validation of liquid chromatography method for the simultaneous determination of metformin and glipizide, gliclazide, glibenclamide or glimperide in plasma Journal of Chromatography B. ,vol. 817, pp. 277- 286 ,(2005) , 10.1016/J.JCHROMB.2004.12.018
Ulrich Bickel, Birgit Grave, Young-Sook Kang, Adriana del Rey, Karlheinz Voigt, No increase in blood–brain barrier permeability after intraperitoneal injection of endotoxin in the rat Journal of Neuroimmunology. ,vol. 85, pp. 131- 136 ,(1998) , 10.1016/S0165-5728(98)00004-6
J.C. Mamputu, N.F. Wiernsperger, G. Renier, Antiatherogenic properties of metformin: the experimental evidence. Diabetes & Metabolism. ,vol. 29, pp. 6- 71 ,(2003) , 10.1016/S1262-3636(03)72790-6