Genetics of Bone Mineralization and Morphology in Inbred Mice: Analysis of the HcB/Dem Recombinant Congenic Strains

摘要: Abstract : Susceptibility to osteoporotic fractures varies widely with genetic factors accounting for ^50% of this variation. Fracture risk is determined by peak bone mass and skeletal morphology achieved in young adulthood the rate extent loss thereafter. This work will analyze genetics first these components through use recombinant congenic mice. We have demonstrated that 27 HcB/Dem strains differ significantly a variety strength related phenotypes at 6 months age. Further, preliminary mapping loci contributing has been carried out. An intercross between HcB/13 HcB/14 allow more accurate subset genes investigation into pairwise epistatic interactions among loci. A cross examining Cola2(sup oim)/+ heterozygotes determination whether segregating differential system map same chromosomal regions identified studies. Further breeding be performed develop true lines refine candidate their positional cloning. Identifying mouse chromosome control mineralization prediction corresponding human synteny facilitate studies problem.