Role of Kisspeptin/GPR54 System in Human Reproductive Axis
作者： Leticia F.G. Silveira , Milena G. Teles , Ericka B. Trarbach , Ana Claudia Latronico
DOI: 10.1159/000312689
关键词: Kisspeptins 、 Reproductive function 、 Biology 、 Sexual maturity 、 Endocrinology 、 Isolated hypogonadotropic hypogonadism 、 Gonadotropin secretion 、 Kisspeptin 、 Human puberty 、 KISS1 Gene 、 Internal medicine
摘要: The kisspeptin-GPR54 signaling complex is a key gatekeeper of human sexual maturation. Kisspeptins, encoded by the KISS1 gene, constitute powerful stimulus for gonadotropin-releasing hormone-induced gonadotropin secretion. In addition, gene target regulation gonadal steroids in both sexes. increase hypothalamic kisspeptin expression at puberty believed to contribute maturation reproductive axis. Homozygous or compound heterozygous loss-of-function mutations GPR54 have been identified familial and sporadic patients with isolated hypogonadotropic hypogonadism without olfactory abnormalities. mice targeted deletions Kiss1 Gpr54 similar failure Study these provides an important contribution understanding role kisspeptin/GPR54 system control development function.
karger.com
sci-hub.se 参考文章(40)
Tetsuya Ohtaki, Yasushi Shintani, Susumu Honda, Hirokazu Matsumoto, Akira Hori, Kimiko Kanehashi, Yasuko Terao, Satoshi Kumano, Yoshihiro Takatsu, Yasushi Masuda, Yoshihiro Ishibashi, Takuya Watanabe, Mari Asada, Takao Yamada, Masato Suenaga, Chieko Kitada, Satoshi Usuki, Tsutomu Kurokawa, Haruo Onda, Osamu Nishimura, Masahiko Fujino, Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor. Nature. ,vol. 411, pp. 613- 617 ,(2001) , 10.1038/35079135
Sandrine Funes, Joseph A Hedrick, Galya Vassileva, Lisa Markowitz, Susan Abbondanzo, Andrei Golovko, Shijun Yang, Frederick J Monsma, Eric L Gustafson, The KiSS-1 receptor GPR54 is essential for the development of the murine reproductive system Biochemical and Biophysical Research Communications. ,vol. 312, pp. 1357- 1363 ,(2003) , 10.1016/J.BBRC.2003.11.066
Richard Quinton, Véronique M. Duke, Alexis Robertson, Jeremy M. W. Kirk, Glenn Matfin, Priyal A. De Zoysa, Christina Azcona, Gavin S. MacColl, Howard S. Jacobs, Gerard S. Conway, Michael Besser, Richard G. Stanhope, Pierre-Marc G. Bouloux, Idiopathic gonadotrophin deficiency: genetic questions addressed through phenotypic characterization Clinical Endocrinology. ,vol. 55, pp. 163- 174 ,(2001) , 10.1046/J.1365-2265.2001.01277.X
Jeremy T. Smith, Matthew J. Cunningham, Emilie F. Rissman, Donald K Clifton, Robert A. Steiner, Regulation of Kiss1 gene expression in the brain of the female mouse Endocrinology. ,vol. 146, pp. 3686- 3692 ,(2005) , 10.1210/EN.2005-0488
W.H. Colledge, Transgenic mouse models to study Gpr54/kisspeptin physiology Peptides. ,vol. 30, pp. 34- 41 ,(2009) , 10.1016/J.PEPTIDES.2008.05.006
M.L. Gottsch, D.K. Clifton, R.A. Steiner, Kisspepeptin-GPR54 signaling in the neuroendocrine reproductive axis Molecular and Cellular Endocrinology. ,vol. 254-255, pp. 91- 96 ,(2006) , 10.1016/J.MCE.2006.04.030
E. Gutiérrez-Pascual, A. J. Martínez-Fuentes, L. Pinilla, M. Tena-Sempere, M. M. Malagón, J. P. Castaño, Direct pituitary effects of kisspeptin: activation of gonadotrophs and somatotrophs and stimulation of luteinising hormone and growth hormone secretion. Journal of Neuroendocrinology. ,vol. 19, pp. 521- 530 ,(2007) , 10.1111/J.1365-2826.2007.01558.X
Milena Gurgel Teles, Suzy DC Bianco, Vinicius Nahime Brito, Ericka B Trarbach, Wendy Kuohung, Shuyun Xu, Stephanie B Seminara, Berenice B Mendonca, Ursula B Kaiser, Ana Claudia Latronico, None, A GPR54-Activating Mutation in a Patient with Central Precocious Puberty The New England Journal of Medicine. ,vol. 358, pp. 709- 715 ,(2008) , 10.1056/NEJMOA073443
Ande West, Patrick J. Vojta, Danny R. Welch, Bernard E. Weissman, Chromosome localization and genomic structure of the KiSS-1 metastasis suppressor gene (KISS1) Genomics. ,vol. 54, pp. 145- 148 ,(1998) , 10.1006/GENO.1998.5566
M. L. Gottsch, M. J. Cunningham, J. T. Smith, S. M. Popa, B. V. Acohido, W. F. Crowley, S. Seminara, D. K. Clifton, R. A. Steiner, A Role for Kisspeptins in the Regulation of Gonadotropin Secretion in the Mouse Endocrinology. ,vol. 145, pp. 4073- 4077 ,(2004) , 10.1210/EN.2004-0431