A new therapeutic trial of secretin in the treatment of intrahepatic cholestasis

摘要: Many animal experiments have been studied on the choleretic effects of secretin. We intended to estimate secretin choleresis in human (15 patients) who had received PTCD or T-tube insertion into common bile duct. Based upon these data and choleresis, was administered 11 patients with prolonged jaundice due intrahepatic cholestasis order evaluate this as a new therapy for jaundice. As controls, eleven treated steroid hormones and/or phenobarbital were used. In all cases biliary drainage, produced remarkable effect high concentration bicarbonate. 9 out secretin, levels serum bilirubin decreased linearly other liver function tests returned normal range. The mean values T1/2 (number days required reduction by half) effective 10.8 days. On hand, that 23.2 These results suggest may be an treatment cholestasis.