Weight stabilisation is associated with improved survival duration and quality of life in unresectable pancreatic cancer.
作者： Wendy Davidson , Susan Ash , Sandra Capra , Judith Bauer , Cancer Cachexia Study Group
DOI: 10.1016/J.CLNU.2003.07.001
关键词: Quality of life 、 Survival rate 、 Internal medicine 、 Post-hoc analysis 、 Medicine 、 Pancreatic cancer 、 Surgery 、 Weight loss 、 Diet therapy 、 Log-rank test 、 Cachexia
摘要: Abstract Background & aims: Cancer-induced weight loss is associated with poor outcomes and common in pancreatic cancer. The aims were to determine whether stabilising for patients unresectable cancer was improved survival quality of life (QoL) identify determinants stabilisation. Methods: A post hoc analysis performed using data from 107 a multicentre trial. Patients categorised as losing (>1 kg lost) or stable (⩽1 kg after an 8 week nutrition intervention period. Group duration (Kaplan Meier) QoL (EORTC QLQ-C30) compared. Predictors stability determined logistic regression analysis. Results: stabilisation survived longer baseline (log rank test 5.53, P=0.019). They also reported higher scores (P=0.037) greater mean energy intake (P Conclusions: Weight over period weight-losing QoL.
ulb.ac.be
uq.edu.au
core.ac.uk
elsevier.com参考文章(52)
Alexandros Polychronidis, Konstantinos N. Syrigos, Anastasios Bounovas, Anastasios J. Karayiannakis, Michail Pitiakoudis, Konstantinos Simopoulos, Serum levels of tumor necrosis factor-alpha and nutritional status in pancreatic cancer patients. Anticancer Research. ,vol. 21, pp. 1355- 1358 ,(2001)
Alter Cl, Palliative and supportive care of patients with pancreatic cancer. Seminars in Oncology. ,vol. 23, pp. 229- 240 ,(1996)
S. A. Jebb, A. E. Black, T. J. Cole, M. B. E. Livingstone, G. R. Goldberg, A. M. Prentice, Critical evaluation of energy intake data using fundamental principles of energy physiology: 2. Evaluating the results of published surveys. European Journal of Clinical Nutrition. ,vol. 45, pp. 583- 599 ,(1991)
W K Evans, D W Nixon, J M Daly, S S Ellenberg, L Gardner, E Wolfe, F A Shepherd, R Feld, R Gralla, S Fine, A randomized study of oral nutritional support versus ad lib nutritional intake during chemotherapy for advanced colorectal and non-small-cell lung cancer. Journal of Clinical Oncology. ,vol. 5, pp. 113- 124 ,(1987) , 10.1200/JCO.1987.5.1.113
SJ Wigmore, JS Falconer, CE Plester, JA Ross, JP Maingay, DC Carter, KCH Fearon, Ibuprofen reduces energy expenditure and acute-phase protein production compared with placebo in pancreatic cancer patients British Journal of Cancer. ,vol. 72, pp. 185- 188 ,(1995) , 10.1038/BJC.1995.300
Sandra Capra, Judith Bauer, Wendy Davidson, Susan Ash, None, Nutritional therapy for cancer-induced weight loss. Nutrition in Clinical Practice. ,vol. 17, pp. 210- 213 ,(2002) , 10.1177/0115426502017004210
Rowan T. Chlebowski, Melanie R. Palomares, Linda Lillington, Mary Grosvenor, Recent implications of weight loss inlung cancer management Nutrition. ,vol. 12, ,(1996) , 10.1016/0899-9007(95)00075-5
D C McMillan, S J Wigmore, K C H Wigmore, P O’Gorman, C E Wright, C S McArdle, A prospective randomized study of megestrol acetate and ibuprofen in gastrointestinal cancer patients with weight loss British Journal of Cancer. ,vol. 79, pp. 495- 500 ,(1999) , 10.1038/SJ.BJC.6690077
J Stuart Falconer, Kenneth CH Fearon, James A Ross, Robert Elton, Stephen J Wigmore, O James James, David C Carter, None, Acute-phase protein response and survival duration of patients with pancreatic cancer Cancer. ,vol. 75, pp. 2077- 2082 ,(1995) , 10.1002/1097-0142(19950415)75:8<2077::AID-CNCR2820750808>3.0.CO;2-9
H.J.N. Andreyev, A.R. Norman, J. Oates, D. Cunningham, Why do patients with weight loss have a worse outcome when undergoing chemotherapy for gastrointestinal malignancies European Journal of Cancer. ,vol. 34, pp. 503- 509 ,(1998) , 10.1016/S0959-8049(97)10090-9