Differential regulation of hepatic glutathione transferase and glutathione peroxidase activities in the rat.

摘要: Abstract The effects of the xenobiotics, i.e. butylated hydroxytoluene, β-naphthoflavone, isosafrole, pregnenolone-16α-carbonitrile, trans -stilbene oxide, 3-methylcholanthrene, phenobarbital, 3,3',4,4'-tetrachlorobiphenyl, 2,2',4,4',5,5'-hexachlorobiphenyl, on rat liver cytosolic glutathione transferase and peroxidase activities have been investigated. Although isozymes (measured by specific substrates ethacrynic acid Δ 5 -androstene-3,17-dione) which shown to possess activity were significantly increased, little or no increase in (toward cumene hydroperoxide, tert -butyl hydroperoxide hydrogen peroxide) was observed. Likewise during a 16-day time course following administration Aroclor 1254 fireMaster BP-6 (each 500mg/kg, i.p.), potent induction seen without any significant increases activities. In fact second week course, there decreases selenium-dependent peroxide). inverse regulation these activities, depression sustained transferases, may direct implications for toxicity polyhalogenated aromatic hydrocarbons.