HLA-A3 increases and HLA-DR1 decreases the risk of acute graft-versus-host disease after HLA-matched sibling bone marrow transplantation for chronic myelogenous leukaemia.

摘要: Frequencies of human leucocyte antigens (HLA)-A, -B and -DR were determined in 751 patients with chronic myelogenous leukaemia (CML) reported to the European Group for Blood Marrow Transplantation after bone marrow transplantation from HLA-identical family donors related occurrence graft-versus-host disease (GVHD). HLA-A3 DR1 significantly associated acute GVHD, first a higher risk (44% HLA-A3(+) versus 34% HLA-A3(-) patients) latter lower (28% HLA-DR1(+) 38% HLA-DR1(-) developing GVHD grade II--IV. Both factors independent known variables as shown multivariate analysis. The results show that MHC alleles independently influence incidence an donor chronic-phase CML. Possible mechanisms might include HLA antigen-specific allele-associated effect, and/or non-specific immune hypo- or hyper-responsiveness.