A TCR alpha chain transgene induces maturation of CD4- CD8- alpha beta+ T cells from gamma delta T cell precursors
作者： Maria Fritsch , Åsa Andersson , Karin Petersson , Fredrik Ivars
DOI: 10.1002/(SICI)1521-4141(199803)28:03<828::AID-IMMU828>3.0.CO;2-X
关键词: Alpha (ethology) 、 Virology 、 T-cell receptor 、 T cell 、 Molecular biology 、 Beta (finance) 、 Alpha chain 、 Biology 、 CD8 、 Gamma delta T cell 、 Population
摘要: The proportion of CD4- CD8- double-negative (DN) alpha beta T cells is increased both in the thymus and peripheral lymphoid organs TCR chain-transgenic mice. In this report we have characterized cell population to elucidate its relationship gamma delta cells. We show that transgenic DN are phenotypically similar but distinct from NK precursors neither rearranged endogenous genes nor been negatively selected by MIsa antigen, suggesting they originate a differentiation stage before onset chain rearrangements CD4/CD8 gene expression. Neither in-frame V D J over-represented population. However, since with functional depleted transgenics, propose population, at least partially, originates those present data lend support view maturation signals lineage-committed can be delivered via heterodimers.
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