Evaluation of hyperbaric oxygen as a chemosensitizer in the treatment of epithelial ovarian cancer in xenografts in mice

摘要: Background. Resistance to chemotherapy is common in bulky hypoxic tumors such as epithelial ovarian cancer. Hyperbaric oxygen (HBO) oxygenates tissues and promotes neovascularization. These unique properties of HBO may help overcome resistance by increasing both tumor perfusion cellular sensitivity. This study was undertaken determine if increases the response cancer cisplatin chemotherapy. Methods. In Phase I,64 nu/nu mice were divided into four groups subcutaneously inoculated with cells from A2780 human cell line. Group 1 served controls. 2 received weekly intraperitoneal (3.15 mg/kg). 3 exposed (dives) at 2.4 atmospheres absolute pressure for 90 minutes, 7 days a week. 4 HBO. II, 72 two similarly inoculated. Both (2.5 not 5 Results. Dramatic neovascularization found (P = 0.0001). There significant 0.014) growth retardation I receiving compared those treated alone. significance noted after just doses but subsequently lost due reduced numbers mice. detectable 10 treatments (2 weeks) maximal 15 (3 weeks). Conclusions. vascularity appears be relationship between increased enhanced that merits further investigation. Cancer 1995 ;75 :2313-22.