Hyperbaric oxygen and malignancies: a potential role in radiotherapy, chemotherapy, tumor surgery and phototherapy.

摘要: Over the past 40 years, hyperbaric oxygen (HBO2) therapy has been recommended and used in a wide variety of medical conditions. In 1950s, HBO2 was first as treatment, addition to radiation, for head neck cancers cervical cancer. Many studies have conducted investigate possible therapeutic effects part cancer management. Evidences showed that improved tumor oxygenation, treatment with during irradiation shown improve radiation response many solid tumors. It delayed injuries soft tissue bony injuries, symptomatic reactions urinary bladder bowel, laryngeal radionecrosis, radiation-induced optic neuropathy, proctitis necrosis brain. also increases sensitivity chemotherapy. A significant improvement obtained when photodynamic (PDT) delivered hyperoxygenation. These were extensively reviewed rational scientific basis further investigations discussed. The possibility combining HBO2, PDT photosensitizers overcome primary secondary carcinoma deserve extensive laboratory clinical research works. is relatively benign few contraindications, even active patients.