Neuromyelitis optica: Passive transfer to rats by human immunoglobulin
作者： Makoto Kinoshita , Yuji Nakatsuji , Takashi Kimura , Masayuki Moriya , Kazushiro Takata
DOI: 10.1016/J.BBRC.2009.06.085
关键词: Autoantibody 、 Antibody 、 Optic neuritis 、 Myelitis 、 Neuromyelitis optica 、 Aquaporin 4 、 Medicine 、 Immunoglobulin G 、 Immunology 、 Multiple sclerosis
摘要: Recurrent attacks of optic neuritis and myelitis are the hallmarks both neuromyelitis optica (NMO) multiple sclerosis (MS). NMO immunoglobulin G (NMO-IgG), which recognizes astrocytic aquaporin-4 (AQP4) water channels, is a specific serum autoantibody that distinguishes from MS. The pathogenic role anti-AQP4 antibody (AQP4-Ab, NMO-IgG) in has been speculated based on several studies vitro. aim this study was to demonstrate pathogenicity AQP4-Ab vivo. We obtained IgG patients who underwent therapeutic plasmapheresis, developed an animal model by passive transfer rats. active lesions rats exhibited pathological characteristics strikingly similar those NMO, marked loss perivascular deposition complements. These findings provide first evidence vivo support efficacy eliminating antibodies plasmapheresis.
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