Physiological abnormalities in experimental allergic encephalomyelitis (EAE). II: Correlation between clinical signs and vestibular hyperreactivity and other signs of brain-stem dysfunction in rats with EAE
作者： C. J. J. Brinkman , P. L. M. Huygen
DOI: 10.1111/J.1600-0404.1984.TB00814.X
关键词: Ataxia 、 Paresis 、 Immunology 、 Paralysis 、 Facial weakness 、 Pathology 、 Mydriasis 、 Reflex 、 Medicine 、 Encephalomyelitis 、 Pupillary light reflex
摘要: – 12 Lewis rats were inoculated with a guinea pig spinal cord tissue preparation. They developed experimental allergic encephalomyelitis (EAE) after 12–14 days manifested by weight loss, tail flaccidity, ataxia, hind limb paresis or paralysis and urinary incontinence. Concomitantly EAE, all animals vestibular hyperreactivity (VH) of canal otolith reflexes. Other signs brain-stem dysfunction also observed: abducens paralysis, facial weakness, tachypnoe mydriasis defective pupillary light reflex. The other abnormalities subsided some delay recovery from clinical whilst histological still present in the CNS.
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