Influence of cerebroside and ganglioside on the encephalitogenic activity of myelin basic protein in guinea pigs.
作者： C. J. J. Brinkman , H. J. ter Laak , O. R. Hommes
DOI: 10.1111/J.1600-0404.1983.TB04557.X
关键词:
摘要: ABSTRACT- The effect of 2 central nervous system glycolipids (cere-broside and ganglioside) on the encephalitogenic activity bovine myelin basic protein (MBP) was studied in guinea pigs. Mixing each these with MBP injection mixtures Freund's incomplete adjuvent (FIA) abrogated resistance to encephalomyelitis upon challenge complete adjuvant (FCA). Primary glycolipid-MBP FCA diminished clinical signs experimental allergic (EAE) as compared primary FCA. Considering amount ganglioside needed optimally induce effects, this phenomenon seemed be aspecific. However, cerebroside, only minor quantities were sufficient, suggesting specific interaction protein. In several aspects, close correlation found between cellular immune measured by skin reactivity development EAE.
sci-hub.se 参考文章(25)
H. M. Wisniewski, H. Lassmann, Chronic Relapsing EAE: Its Application to Study of Human Inflammatory Demyelinating Diseases Springer, Berlin, Heidelberg. pp. 11- 17 ,(1980) , 10.1007/978-3-642-67554-6_2
Y. Nagai, K. Akiyama, S. Kotani, T. Shimono, T. Shiba, T. Yamamoto, Refinement of the EAE Model Utilizing Various Synthetic Adjuvants and Bacterial Fractions: An Attempt to Produce a Chronic Model of EAE Springer, Berlin, Heidelberg. pp. 18- 27 ,(1980) , 10.1007/978-3-642-67554-6_3
Peter E. Braun, Molecular Architecture of Myelin Myelin. pp. 91- 115 ,(1977) , 10.1007/978-1-4615-7514-6_3
D C Morrison, S Raziuddin, R F Kibler, Experimental allergic encephalomyelitis in Lewis rats: inhibition by bacterial lipopolysaccharides and acquired resistance to reinduction by challenge with myelin basic protein. Journal of Immunology. ,vol. 127, pp. 16- 20 ,(1981)
William T. Norton, Isolation and Characterization of Myelin Myelin. pp. 161- 199 ,(1977) , 10.1007/978-1-4615-7514-6_5
Marian W. Kies, Experimental Allergic Encephalomyelitis Biology of Brain Dysfunction. pp. 185- 224 ,(1973) , 10.1007/978-1-4684-2670-0_5
D C Morrison, S Raziuddin, R F Kibler, Prevention of experimental allergic encephalomyelitis by bacterial lipopolysaccharides: inhibition of cell-mediated immunity. Journal of Immunology. ,vol. 127, pp. 13- 16 ,(1981)
Lynn E. Spitler, Christine M. von Muller, H. Hugh Fudenberg, Edwin H. Eylar, EXPERIMENTAL ALLERGIC ENCEPHALITIS : DISSOCIATION OF CELLULAR IMMUNITY TO BRAIN PROTEIN AND DISEASE PRODUCTION Journal of Experimental Medicine. ,vol. 136, pp. 156- 174 ,(1972) , 10.1084/JEM.136.1.156
G. E. Deibler, R. E. Martenson, M. W. Kies, Large scale preparation of myelin basic protein from central nervous tissue of several mammalian species. Preparative Biochemistry & Biotechnology. ,vol. 2, pp. 139- 165 ,(1972) , 10.1080/00327487208061467
Claude C. Bernard, Gilles Lamoureux, Inhibition by serum of encephalitogenic activity of myelin basic protein: nature of the serum factor responsible. Cellular Immunology. ,vol. 16, pp. 182- 191 ,(1975) , 10.1016/0008-8749(75)90197-5