Wnt signaling is required for thymocyte development and activates Tcf-1 mediated transcription
作者： Frank J. T. Staal , Jan Meeldijk , Petra Moerer , Philippe Jay , Barbara C. M. van de Weerdt
DOI: 10.1002/1521-4141(200101)31:1<285::AID-IMMU285>3.0.CO;2-D
关键词: T cell 、 LRP6 、 Cell biology 、 LRP5 、 Enhancer 、 Transcription factor 、 Wnt signaling pathway 、 Biology 、 Beta-catenin 、 Molecular biology 、 Thymocyte
摘要: T cell factor / lymphocyte enhancer (Tcf/Lef) transcription factors complex with the transcriptional co-activator beta-catenin to transduce Wnt signals in a variety of developmental systems. The prototypic family member Tcf-1 is highly expressed lineage cells. Tcf1-/- mice are defective cycling early thymocyte stages. Here, we show that interaction required for full development. This may be established by mediated Wnt1 and Wnt4, leading increased Tcf-dependent activity thymocytes, as demonstrated Tcf-LacZ reporter mice. Transduction fetal thymocytes Wnt4 results survival an vitro culture system. Retroviral expression soluble receptor mutants block signaling inhibits These imply important role cascade
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