Bone cell biology: the regulation of development structure, and function in the skeleton

作者: Sandy C. Marks , Steven N. Popoff

DOI: 10.1002/AJA.1001830102

关键词: PopulationInternal medicineCell cultureCell biologyBone resorptionHaematopoiesisMesenchymal stem cellResorptionStructure and functionEndocrinologyBiologyBone cell

摘要: Bone cells compose a population of heterogeneous origin but restricted function with respect to matrix formation, mineralization, and resorption. The local, mesenchymal the which form skeleton contrasts their extraskeletal, hemopoietic relatives under bone resorption takes place. However, functions these two diverse populations are remarkably related interdependent. cell regulation, presently in its infancy, is complicated cascade involving plethora local systemic factors, including some components skeletal matrices other organ systems. Thus, any understanding regulation key ingredient not only development, maintenance, repair also prevention treatment disorders.

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