Antibodies and Vaccines as Novel Cancer Therapeutics
作者： SVETOMIR N. MARKOVIC , ESTEBAN CELIS
DOI: 10.1016/B978-012088561-9/50008-9
关键词: Immunotoxin 、 Antigen 、 Immunization 、 Immunology 、 Monoclonal antibody 、 Immunogenicity 、 Antibody 、 Biology 、 Virology 、 Cancer vaccine 、 Immunoconjugate
摘要: Publisher Summary This chapter discusses the basic principles of antitumor antibody and vaccine development with illustrative examples agents currently in clinical use. The realm antibody-based cancer immunotherapeutics is divided into two categories, including unmodified monoclonal antibodies cytotoxic, regulatory, immunization properties, immunoconjugates. most significant developments has been discovery demonstrating direct anti-tumor cytotoxic properties. Immunotoxins represent largest component immunoconjugate effort. Cancer vaccines an attempt to actively immunize patients against single or multiple tumor-specific antigens. role immune adjuvants enhance immunogenicity antigen. An example a antigen containing immunodominant peptides capable stimulating T-cell responses MAGE-1. MAGE-1 encoded by gene spanning 5 kb, 2419 base pair sequence produces predicted protein product 26 kDa.
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