Neuroticism and Individual Differences in Neural Function in Unmedicated Major Depression: Findings From the EMBARC Study

摘要: Abstract Background Personality dysfunction represents one of the only predictors differential response between active treatments for depression to have replicated. We examine whether depressed patients with higher neuroticism scores, a marker personality dysfunction, show differences compared lower scores in functioning two brain regions associated treatment response, anterior cingulate and insula cortices. Methods Functional magnetic resonance imaging data during an emotional Stroop task were collected from 135 adults major depressive disorder at four academic medical centers participating EMBARC (Establishing Moderators Biosignatures Antidepressant Response Clinical Care) study. Secondary analyses conducted including sample 28 healthy subjects. Results In whole-brain analyses, among was increased activity connectivity right cortex incongruent congruent stimuli (all k ≥ 281, all p Conclusions This study provides convergent evidence importance as brain-based clinically meaningful individual depression. is critical next step linking replicated clinical predictor antidepressant underlying function.