Functional similarities among genes regulated by OCT4 in human mesenchymal and embryonic stem cells.

摘要: OCT4 is a master transcriptional regulator, which mediates pluripotency in ESCs through inhibition of tissue-specific and promotion stem cell-specific genes. Suppression OCT4, along with other regulators pluripotency, such as SOX2 NANOG, has been correlated cell-fate specification lineage-specific differentiation. Recent reports have shown the expression adult MSCs but not ascribed functional homology ESCs. are mesoderm-derived cells, primarily resident bone marrow, that undergo differentiation to generate specialized cells stroma, fat, bone, cartilage. We previously demonstrated plasticity their ability neuronal cells. Here, we show provides similar regulatory circuitries human ESCs, using chromatin immunoprecipitation-DNA selection ligation technology loss-of-function studies. were found express embryonic transcription factors SOX2. In addition, was (a) target genes (b) promote MSC-specific genes, (c) regulate MSC cell cycle progression. The results suggest mechanisms for implications regarding plasticity. Disclosure potential conflicts interest at end this article.