Association of steroid and xenobiotic receptor (SXR) and multidrug resistance 1 (MDR1) gene expression with survival among patients with invasive bladder carcinoma

摘要: What’s known on the subject? and What does study add? SXR MDR1 are as responsible for chemo radiotherapy resistance in some cancers, like kidney cancer (MDR1). Invasive bladder is an aggressive disease, with different behaviour upon its tumoral stage, also within same therefore molecular markers sought. This shows a new marker, which has shown predictor bad prognosis therefore, allowing us better patient selection therapies. OBJECTIVE • To investigate prognostic value of steroid xenobiotic receptor (SXR) multidrug 1 (MDR1) gene expression relation to survival among patients invasive cancer. PATIENTS AND METHODS • The prospective included 67 diagnosed treated radical cystectomy at one two institutions. • SXR was assessed by real-time quantitative polymerase chain reaction (RT-PCR) normal tissue from frozen surgical specimens. RESULTS • Patients were followed mean 29 months; 31 (46%) had progression. • In univariate analysis, significant predictors overall (OS) pathological lymph node (LN) status, histological grade, vascular-lymphatic invasion, SXR expression. • In multivariate independent OS LN status (odds ratio [OR], 2.96; P= 0.034), invasion (OR, 2.50; 0.029), 1.05, 0.03). • Among 51 negative LNs (pN0), expression, stage. In 1.06; 0.01) 3.27; 0.03) independently associated survival. • Within pN0 group, shorter progression-free than did those without (P= 0.004). This association persisted N0 subgroup stage pT3–pT4 disease 0.028). However, pN1 group not have any influence. CONCLUSIONS • For cancer, standard predictors. • Its maximum importance appears be pT3–pT4 pN0 disease.